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COVID-19'a Karşı Geliştirilen Yeni DNA Aşısı ZyCov-D'ye Acil Kullanım Onayı - HAKANSEYHAN
Hindistan İlaç Denetçisi Müdürlüğü, ZyCov-D aşısı için acil kullanım izni verildiğini duyurdu. Bu, COVID-19’a karşı onaylanmış ilk DNA aşısı olarak öne çıkıyor ve ilaç şirketi şirketi Cadila , hastalığa karşı yüzde 66 etkinliğe haiz bulunduğunu söylüyor.
Aşı, 28 gün arayla üç doz halinde verilecek ve mevcud verilere gore güvenli ve iyi tolere ediliyor. 12 ile 18 yaşları arasındaki 1.000 ergen de dahil olmak suretiyle 28.000’den fazla gönüllüde kontrol edildi. Onay, bu yaş grubunun Hindistan’da aşılanmasına izin verecek. Şirket, her yıl 100 ila 120 milyon doz içinde üretim yapmayı hedefliyor.
Caida başkanı Mr. Pankaj R. Patel, “Hindistan inovasyonunun bir ürünü olan, insan kullanımına sunulan dünyanın ilk DNA aşısı haline gelen ve dünyanın en büyük bağışıklık kazandırma girişimini destekleyen ZyCoV-D ile zamanı bir dönüm noktasındayız. Aşımızın COVID-19 ile bu mücadeleye katkıda bulunacağı ve bilhassa 12-18 yaş grubunda daha büyük bir nüfusun aşılanmasını sağlayacağı için bilhassa mutluyuz. Bu çabayı destekleyen tüm araştırmacılara, klinik araştırma araştırmacılarına, gönüllülere ve düzenleyicilere teşekkür etmek isterim ” diyor.
DNA aşısı, bağışıklık tepkisini uyarmak için genetiği değiştirilmiş ve zararsız bir virüsün kullanıldığı AstraZeneca aşısı şeklinde vektör bazlı aşılardan değişik çalışıyor. Bunun yerine, çoğalabilen ve insan vücudunu virüsün sivri proteinlerini üretmesi için uyarmak için kullanılabilen ufak bir DNA döngüsü olan bir plazmit kullanıyor.
Bu proteinler, COVID-19’a yol açan virüs olan SARS-CoV-2 tarafınca kendisini hücrelere bağlamak için kullanılıyor. Bu tür proteinler kendi organizmamız tarafınca üretildiğinde, bir bağışıklık tepkisi oluşturuyor. Bağışıklık sistemimiz bunlarla süratli bir halde ilgilenilmesi icap ettiğini öğreniyor.
DNA aşılarının pozitif yanları, bu tür aşıları süratli, ucuz ve güvenli bir halde üretebilme kabiliyeti. Bununla beraber fazlaca süratli bir halde güncellenmiş sürümlerin geliştirilmesine olanak tanıyor. Bu, dünya genelinde birçok ülkede en yaygın olan Delta şeklinde varyantlara karşı mücadelede bilhassa yararlı olabilir. Düzgüsel bir buzdolabı sıcaklığında saklanıyor ve oda sıcaklığında aylarca bozulmadan kalabiliyor.
Klinik araştırmanın birinci aşamasından elde edilmiş veriler, kısa sürede Lancet tarafınca gösterilen EClinicalMedicine dergisinde gösterildi. Bir DNA aşısı üretmeye yönelik önceki girişimler işe yaramadığı için, tam denemeden elde edilmiş verilerde kesinlikle fazlaca fazla ilgi çekici kısım bulunuyor. Bilhassa, birkaç yaklaşım hayvan modellerinde büyük ümit vaat etti, sadece insanlara çeviri edilemedi. Yaklaşım başarıya ulaşmış olursa, bu devrim durumunda olabilir.
Araştırılmakta olan yüzlerce DNA aşısı var ve bunların bir çok, öteki birçok hastalık içinde kanser, paraziter hastalıklar, grip ve HIV ile savaşmak için bu yaklaşımı kullanmayı umuyor…
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