20";display:block;height:0;overflow:hidden}.clearfix:after{clear:both}.tie-container,#tie-wrapper{height:100%;min-height:650px}.tie-container{position:relative;overflow:hidden}#tie-wrapper{background:#fff;position:relative;z-index:108;height:100%;margin:0 auto}.container-wrapper{background:#fff;border:1px solid rgba(0,0,0,.1);border-radius:2px;padding:30px}#content{margin-top:30px}@media (max-width:991px){#content{margin-top:15px}}.site-content{-ms-word-wrap:break-word;word-wrap:break-word}.theme-header{background:#fff;position:relative;z-index:999}.theme-header:after{content:"";display:table;clear:both}.theme-header.has-shadow{box-shadow:rgba(0,0,0,.1) 0px 25px 20px -20px}#menu-components-wrap{display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;width:100%;-webkit-flex-wrap:wrap;-ms-flex-wrap:wrap;flex-wrap:wrap}.header-layout-4 #menu-components-wrap{-webkit-justify-content:flex-start;-ms-flex-pack:start;justify-content:flex-start}.header-layout-4 #menu-components-wrap .main-menu-wrap{-webkit-flex-grow:2;-ms-flex-positive:2;flex-grow:2}.header-layout-4 #menu-components-wrap .flex-placeholder{-webkit-flex-grow:1;-ms-flex-positive:1;flex-grow:1}#logo{margin-top:40px;margin-bottom:40px;display:block;float:left}#logo img{vertical-align:middle}#logo a{display:inline-block}#tie-logo-inverted,#tie-sticky-logo-inverted{display:none}@media (max-width:991px){#theme-header.has-normal-width-logo #logo{margin:14px 0!important;text-align:left;line-height:1}#theme-header.has-normal-width-logo #logo img{width:auto;height:auto;max-width:190px}}@media (max-width:479px){#theme-header.has-normal-width-logo #logo img{max-width:160px;max-height:60px!important}}@media (max-width:991px){#theme-header.mobile-header-default.header-layout-1 .header-layout-1-logo{-webkit-flex-grow:10;-ms-flex-positive:10;flex-grow:10}}.components{display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-align-items:center;-ms-flex-align:center;align-items:center;-webkit-justify-content:end;-ms-flex-pack:end;justify-content:end}.components>li{position:relative}.components>li.social-icons-item{margin:0}.components>li>a{display:block;position:relative;width:30px;text-align:center;font-size:16px;white-space:nowrap}.components .search-bar form{width:auto;background:rgba(255,255,255,.1);line-height:36px;border-radius:50px;position:relative}.components #search-input{border:0;width:100%;background:0 0;padding:0 35px 0 20px;border-radius:0;font-size:inherit}.components #search-submit{position:absolute;right:0;top:0;width:40px;line-height:inherit;color:#777;background:0 0;font-size:15px;padding:0;border:none}.header-layout-1 #menu-components-wrap{display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-justify-content:flex-end;-ms-flex-pack:end;justify-content:flex-end}.header-layout-1 .main-menu-wrapper{display:table;width:100%}.header-layout-1 #logo{line-height:1;float:left;margin-top:20px;margin-bottom:20px}.header-layout-1 .header-layout-1-logo{display:table-cell;vertical-align:middle;float:none}@media (max-width:991px){.header-layout-1 .main-menu-wrapper{border-width:0;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-flow:row nowrap;-ms-flex-flow:row nowrap;flex-flow:row nowrap;-webkit-align-items:center;-ms-flex-align:center;align-items:center;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between}}.mobile-header-components{display:none;z-index:10;height:30px;line-height:30px;-webkit-flex-wrap:nowrap;-ms-flex-wrap:nowrap;flex-wrap:nowrap;-webkit-flex:1 1 0%;-ms-flex:1 1 0%;flex:1 1 0%}.mobile-header-components .components{float:none;display:-webkit-flex!important;display:-ms-flexbox!important;display:flex!important;-webkit-justify-content:stretch;-ms-flex-pack:stretch;justify-content:stretch}.mobile-header-components .components li.custom-menu-link{display:inline-block;float:none}.mobile-header-components .components li.custom-menu-link>a{width:20px;padding-bottom:15px}.header-layout-1.main-nav-dark .mobile-header-components .components li.custom-menu-link>a{color:#fff}.mobile-header-components [class^=tie-icon-]{font-size:18px;width:20px;height:20px;vertical-align:middle}.mobile-header-components .tie-mobile-menu-icon{font-size:20px}.mobile-header-components .nav-icon{display:inline-block;width:20px;height:2px;background-color:var(--base-color);position:relative;top:-4px}.mobile-header-components .nav-icon:before,.mobile-header-components .nav-icon:after{position:absolute;right:0;background-color:var(--base-color);content:'';display:block;width:100%;height:100%;-webkit-transform:translateZ(0);transform:translateZ(0);-webkit-backface-visibility:hidden;backface-visibility:hidden}.mobile-header-components .nav-icon:before{-webkit-transform:translateY(-7px);-ms-transform:translateY(-7px);transform:translateY(-7px)}.mobile-header-components .nav-icon:after{-webkit-transform:translateY(7px);-ms-transform:translateY(7px);transform:translateY(7px)}.main-nav-dark.header-layout-1 .mobile-header-components .nav-icon,.main-nav-dark.header-layout-1 .mobile-header-components .nav-icon:before,.main-nav-dark.header-layout-1 .mobile-header-components .nav-icon:after{background-color:#fff}#mobile-header-components-area_1 .components li.custom-menu-link>a{margin-right:15px}#mobile-header-components-area_2 .components{-webkit-flex-direction:row-reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}#mobile-header-components-area_2 .components li.custom-menu-link>a{margin-left:15px}@media (max-width:991px){#tie-body #mobile-container,.mobile-header-components{display:block}#slide-sidebar-widgets{display:none}}.top-nav{background-color:#fff;position:relative;z-index:10;line-height:40px;border:1px solid rgba(0,0,0,.1);border-width:1px 0;color:var(--base-color);clear:both}.main-nav-below.top-nav-above .top-nav{border-top-width:0}.top-nav a:not(.button):not(:hover){color:var(--base-color)}.topbar-wrapper{display:-webkit-flex;display:-ms-flexbox;display:flex;min-height:40px}.top-nav .tie-alignleft,.top-nav .tie-alignright{-webkit-flex-grow:1;-ms-flex-positive:1;flex-grow:1;position:relative}.top-nav.has-breaking-news .tie-alignleft{-webkit-flex:1 0 100px;-ms-flex:1 0 100px;flex:1 0 100px}.top-nav.has-breaking-news .tie-alignright{-webkit-flex-grow:0;-ms-flex-positive:0;flex-grow:0;z-index:1}.topbar-today-date{float:left;padding-right:15px;-webkit-flex-shrink:0;-ms-flex-negative:0;flex-shrink:0}@media (max-width:991px){.topbar-today-date,.theme-header .components{display:none}}.breaking{display:none}.main-nav-wrapper{position:relative;z-index:4}.main-nav{background-color:var(--main-nav-background);color:var(--main-nav-primary-color);position:relative;border:1px solid var(--main-nav-main-border-color);border-width:1px 0}.main-menu-wrapper{position:relative}@media (min-width:992px){.header-menu .menu{display:-webkit-flex;display:-ms-flexbox;display:flex}.header-menu .menu a{display:block;position:relative}.header-menu .menu>li>a{white-space:nowrap}.header-menu .menu .sub-menu a{padding:8px 10px}.header-menu .menu ul:not(.sub-menu-columns):not(.sub-menu-columns-item):not(.sub-list):not(.mega-cat-sub-categories):not(.slider-arrow-nav){box-shadow:0 2px 5px rgba(0,0,0,.1)}.header-menu .menu ul li{position:relative}.header-menu .menu ul a{border-width:0 0 1px}#main-nav{z-index:9;line-height:60px}.main-menu .menu>li>a{padding:0 14px;font-size:14px;font-weight:700}.main-menu .menu>li>.menu-sub-content{border-top:2px solid var(--main-nav-primary-color)}.main-menu .menu ul{line-height:20px;z-index:1}.main-menu .menu .sub-menu .tie-menu-icon,.main-menu .menu .mega-recent-featured-list .tie-menu-icon{width:20px}.main-menu .menu-sub-content{background:var(--main-nav-background);display:none;padding:15px;width:230px;position:absolute;box-shadow:0 3px 4px rgba(0,0,0,.2)}.main-menu .menu-sub-content a{width:200px}nav.main-nav.menu-style-default .menu>li.tie-current-menu{border-bottom:5px solid var(--main-nav-primary-color);margin-bottom:-5px}nav.main-nav.menu-style-default .menu>li.tie-current-menu>a:after{content:"";width:20px;height:2px;position:absolute;margin-top:17px;left:50%;top:50%;bottom:auto;right:auto;-webkit-transform:translateX(-50%) translateY(-50%);-ms-transform:translateX(-50%) translateY(-50%);transform:translateX(-50%) translateY(-50%);background:#2c2f34}nav.main-nav.menu-style-solid-bg .menu>li.tie-current-menu>a{background-color:var(--main-nav-primary-color);color:var(--main-nav-contrast-primary-color)}.main-nav .menu a,.main-nav .components li a{color:var(--main-nav-text-color)}.main-nav-dark{--main-nav-background:#1f2024;--main-nav-secondry-background:rgba(0,0,0,.2);--main-nav-primary-color:var(--brand-color);--main-nav-contrast-primary-color:var(--bright-color);--main-nav-text-color:#fff;--main-nav-secondry-text-color:rgba(225,255,255,.5);--main-nav-main-border-color:rgba(255,255,255,.07);--main-nav-secondry-border-color:rgba(255,255,255,.04)}.main-nav-dark .main-nav{border-width:0}}@media (min-width:992px){header .menu-item-has-children>a:before,.mega-menu>a:before{content:'';position:absolute;right:10px;top:50%;bottom:auto;-webkit-transform:translateY(-50%);-ms-transform:translateY(-50%);transform:translateY(-50%);font-family:'tiefonticon'!important;font-style:normal;font-weight:400;font-variant:normal;text-transform:none;content:"\f079";font-size:11px;line-height:1}.menu>.menu-item-has-children:not(.is-icon-only)>a,.menu .mega-menu:not(.is-icon-only)>a{padding-right:25px}}@media (min-width:992px){.header-layout-1.main-nav-below.top-nav-above .main-nav{margin-top:-1px;border-top-width:0}.header-layout-1.main-nav-below.top-nav-above .breaking-title{top:0;margin-bottom:-1px}}.header-layout-1.has-shadow:not(.top-nav-below) .main-nav{border-bottom:0!important}@media only screen and (min-width:992px) and (max-width:1100px){.main-nav .menu>li:not(.is-icon-only)>a{padding-left:7px;padding-right:7px}.main-nav .menu>li:not(.is-icon-only)>a:before{display:none}}@media (max-width:991px){#sticky-logo{display:none}}#main-nav:not(.fixed-nav) #sticky-logo,#main-nav:not(.fixed-nav) .flex-placeholder{display:none}@media (min-width:992px){#sticky-logo{overflow:hidden;float:left;vertical-align:middle}#sticky-logo a{line-height:1;display:inline-block}#sticky-logo img{position:relative;vertical-align:middle;padding:8px 10px;top:-1px;max-height:50px}.header-layout-1 #sticky-logo img{padding:0}.header-layout-1:not(.has-custom-sticky-logo) #sticky-logo{display:none}.theme-header #sticky-logo img{opacity:0;visibility:hidden;width:0!important;-webkit-transform:translateY(75%);-ms-transform:translateY(75%);transform:translateY(75%)}.header-layout-1 .flex-placeholder{-webkit-flex-grow:1;-ms-flex-positive:1;flex-grow:1}}@media (max-width:991px){#tie-wrapper header#theme-header{box-shadow:none;background:0 0!important}.header-layout-1 .main-nav{border-width:0;box-shadow:0 3px 7px 0 rgba(0,0,0,.1)}.header-layout-1 .main-nav{background-color:#fff}.main-nav-dark.header-layout-1 .main-nav{background-color:#1f2024}.header-layout-1 #menu-components-wrap{display:none}.main-menu-wrapper .main-menu-wrap{width:100%}}.main-nav-dark .main-nav input{color:#ccc}@media (max-width:767px){.magazine1:not(.has-builder):not(.error404) .main-content,.magazine1:not(.has-builder):not(.error404) .sidebar{padding-left:0;padding-right:0}}input{border:1px solid rgba(0,0,0,.1);color:var(--base-color);font-size:13px;outline:none;padding:10px 12px;line-height:23px;border-radius:2px;max-width:100%;background-color:transparent}input:not([type=checkbox]):not([type=radio]){-webkit-appearance:none;-moz-appearance:none;appearance:none;outline:none}@media (max-width:767px){input:not([type=submit]){font-size:16px!important}}.button,[type=submit]{width:auto;position:relative;background-color:var(--tie-buttons-color,var(--brand-color));color:var(--tie-buttons-text,var(--bright-color));border-radius:var(--tie-buttons-radius,2px);border:var(--tie-buttons-border-width,0) solid var(--tie-buttons-border-color,var(--brand-color));padding:10px 25px;margin:0;font-weight:600;font-size:14px;display:inline-block;text-align:center;line-height:21px;text-decoration:none;vertical-align:middle;-webkit-appearance:none;-moz-appearance:none;appearance:none}@media (min-width:992px){.sidebar-right .main-content{float:left}.sidebar-right .sidebar{float:right}.sidebar-right.magazine1 .main-content{padding-right:3px}}.post-thumb{position:relative;height:100%;display:block;-webkit-backface-visibility:hidden;backface-visibility:hidden;-webkit-transform:rotate(0);-ms-transform:rotate(0);transform:rotate(0)}.post-thumb img{width:100%;display:block}.post-thumb .post-cat-wrap{position:absolute;bottom:10px;margin:0;right:10px}.post-meta{margin:10px 0 8px;font-size:12px;overflow:hidden}.post-meta,.post-meta a:not(:hover){color:#666}.post-meta .meta-item{margin-right:8px;display:inline-block}.post-meta .meta-item.tie-icon:before{padding-right:3px}.post-meta .meta-item.date:before{content:"\f017"}.post-meta .meta-item.meta-comment:before{content:"\f086"}.post-meta .tie-alignright .meta-item:last-child{margin:0!important}@media (max-width:767px){.entry-header .post-meta>span,.entry-header .post-meta>div,.main-content .post-meta>span,.main-content .post-meta>div{float:left}}.post-cat-wrap{position:relative;z-index:3;margin-bottom:5px;font-weight:400;font-family:inherit!important;line-height:0;display:block}.post-cat{display:inline-block;background:var(--brand-color);color:var(--bright-color);padding:0 11px;font-size:13px;line-height:2em;margin-right:4px;position:relative;white-space:nowrap;word-wrap:normal;letter-spacing:0;border-radius:4px}.post-cat:first-child:last-child{margin:0}#breadcrumb{margin:50px 0 0}#breadcrumb,#breadcrumb a:not(:hover){color:#666}#breadcrumb .delimiter{margin:0 3px;font-style:normal}.entry-header-outer #breadcrumb{margin:0 0 20px;padding:0}@media (max-width:767px){.single-post #breadcrumb .current,.single-post #breadcrumb em:last-of-type{display:none}}.author-avatar{display:block}.author-avatar img{border-radius:50%;max-width:111px;object-fit:cover;aspect-ratio:1}.social-icons-item{float:right;margin-left:6px;position:relative}.social-icons-item .social-link span{color:var(--base-color);line-height:unset}.social-icons-widget .social-icons-item .social-link{width:24px;height:24px;line-height:24px;padding:0;display:block;text-align:center;border-radius:2px}.top-nav .components>li.social-icons-item .social-link:not(:hover) span{color:var(--base-color)}.social-icons-item .facebook-social-icon{background-color:#4080ff!important}.social-icons-item .facebook-social-icon span{color:#4080ff}.social-icons-item .twitter-social-icon{background-color:#000!important}.social-icons-item .twitter-social-icon span{color:#000}.social-icons-item .instagram-social-icon{background-color:#c13584!important}.social-icons-item .instagram-social-icon span{color:#c13584}.social-icons-item .youtube-social-icon{background-color:#ef4e41!important}.social-icons-item .youtube-social-icon span{color:#ef4e41}ul:not(.solid-social-icons) .social-icons-item a:not(:hover){background-color:transparent!important}.solid-social-icons .social-link{background-color:var(--base-color)}.dark-skin .solid-social-icons .social-link{background-color:#27292d;border-color:#27292d}.solid-social-icons .social-link span{color:#fff!important}.entry-header{padding:30px 30px 0;margin-bottom:20px}@media (max-width:991px){.entry-header{padding:20px 20px 0}}@media (max-width:767px){.container-wrapper{padding:20px 15px}}.tabs{max-height:75px;width:100%;padding:0;border:1px solid rgba(0,0,0,.1);border-width:0 0 1px;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-flow:row wrap;-ms-flex-flow:row wrap;flex-flow:row wrap}.tabs li{display:inline-block;position:relative;padding:0!important}.tabs a{background:rgba(0,0,0,.02);display:block;text-align:center;border:1px solid rgba(0,0,0,.1);border-width:0 1px 1px 0;font-size:15px}.tabs a:not(:hover){color:var(--base-color)}.tabs>li>a{line-height:65px;padding:0 15px;border-bottom-color:transparent}.tab-content{padding:30px;display:none}.tab-content{position:relative}@media (max-width:767px){.tab-content{padding:20px}}.tab-content-elements li{opacity:0}.tab-content:not(.is-not-active):first-of-type{display:block}.tab-content:not(.is-not-active):first-of-type .tab-content-elements li{opacity:1}.tabs-container-wrapper{padding:0!important}.normal-side .tabs{display:-webkit-flex;display:-ms-flexbox;display:flex}.normal-side .tabs li{-webkit-flex-grow:1;-ms-flex-positive:1;flex-grow:1}.normal-side .tabs a{overflow:hidden;text-overflow:ellipsis;white-space:nowrap;padding:0 10px!important}.normal-side .tabs li:last-child a{border-right-width:0}@media (max-width:320px){.normal-side .tabs{max-height:none;border-bottom:0}.normal-side .tabs li{display:block;width:100%;float:none}.normal-side .tabs a{border-bottom-color:rgba(0,0,0,.1);border-width:0 0 1px}}.block-head-1 .the-global-title{position:relative;font-size:17px;padding:0 0 15px;border-bottom:2px solid rgba(0,0,0,.1);margin-bottom:20px}.block-head-1 .the-global-title:after{content:"";background:#2c2f34;width:40px;height:2px;position:absolute;bottom:-2px;left:0}.block-head-1 .the-global-title:before{content:"";width:0;height:0;position:absolute;bottom:-5px;left:0;border-left:0;border-right:5px solid transparent;border-top:5px solid #2c2f34}.block-head-1 .dark-skin .widget-title:after{background:#fff}.block-head-1 .dark-skin .widget-title:before{border-top-color:#fff}.block-head-1 .dark-skin .the-global-title{color:#fff;border-bottom-color:rgba(255,255,255,.1)}.side-aside{position:fixed;top:0;z-index:111;visibility:hidden;width:350px;max-width:100%;height:100%;background:#fff;background-repeat:no-repeat;background-position:center top;background-size:cover;overflow-y:auto}@media (min-width:992px){.side-aside{right:0;-webkit-transform:translate(350px,0);-ms-transform:translate(350px,0);transform:translate(350px,0)}}.site-footer .widget-title-icon{display:none}.dark-skin{--lazyload-loading-color:#161717}.dark-skin{background-color:var(--tie-dark-skin-bg-main,#1f2024);color:#fff}.dark-skin input:not([type=submit]){color:#ccc}.dark-skin a:not(:hover){color:#fff}.dark-skin .post-meta{color:#ccc!important}.dark-skin input:not([type=submit]){border-color:rgba(255,255,255,.1)}.dark-skin .container-wrapper{background-color:var(--tie-dark-skin-bg-main,#1f2024);border-color:rgba(255,255,255,.1)}.dark-skin .widget a:not(:hover),.dark-skin .widget-title{color:#fff}.dark-skin .widget-title-icon{color:#ccc}.sidebar .container-wrapper{margin-bottom:30px}@media (max-width:991px){.sidebar .container-wrapper{margin-bottom:15px}}@media (max-width:991px){.has-sidebar .sidebar{margin-top:15px}}.widget-title{position:relative}.widget-title .the-subtitle{font-size:15px;min-height:15px}.widget-title-icon{position:absolute;right:0;top:1px;color:#b9bec3;font-size:15px}.widget-title-icon:before{content:"\f08d"}.post-widget-body{padding-left:125px}.post-widget-body .post-title{font-size:14px;line-height:1.4;margin-bottom:5px}.post-widget-thumbnail{float:left;margin-right:15px;position:relative}.post-widget-thumbnail img.tie-small-image{width:110px}.widget li{padding:6px 0}.widget li:first-child{padding-top:0}.widget li:last-child{padding-bottom:0;border-bottom:0}.widget li:after{clear:both;display:table;content:""}.widget .post-meta{margin:2px 0 0;font-size:11px;line-height:17px}.posts-list .widget-title-icon:before{content:"\f0f6"}.posts-list-big-first .posts-list-items li:first-child{padding-bottom:20px}.posts-list-big-first li:first-child .post-widget-thumbnail{width:100%;margin-right:0;margin-bottom:10px}.posts-list-big-first li:first-child .post-widget-thumbnail a{min-height:40px}.posts-list-big-first li:first-child .post-widget-body{padding-left:0}.posts-list-big-first li:first-child .post-title{font-size:18px}@media (max-width:991px){.posts-list-big-first .posts-list-items{overflow:hidden}.posts-list-big-first li{width:48%;float:left}.posts-list-big-first li:nth-child(2){padding-top:0}.posts-list-big-first li:nth-child(2n){float:right}.posts-list-big-first li:nth-child(2n+1){clear:both}.posts-list-big-first li:nth-child(2),.posts-list-big-first li:nth-child(3){float:right;clear:none}}@media (max-width:670px){.posts-list-big-first li{width:100%}.posts-list-big-first li:nth-child(2){padding-top:12px}}form.search-form{overflow:auto;position:relative;width:100%;margin-top:10px}.search-field{float:left;width:73%;padding:8px 15px}.search-submit[type=submit]{float:right;padding:10px 5px;margin-left:2%;width:25%}.login-widget .widget-title-icon:before{content:"\f023"}.login-widget form input[type=text],.login-widget form input[type=password]{width:100%;float:none;margin-bottom:15px}.login-widget .pass-container{position:relative}.login-widget .pass-container input[type=password]{padding-right:70px}.login-widget .forget-text{position:absolute;right:15px;line-height:45px;top:0;font-size:12px}.login-widget .forget-text:not(:hover){color:#666}.login-widget .rememberme{display:block;margin-bottom:15px}.login-widget .register-link{margin:8px 0 0;display:block;text-align:center}.tab-content-comments .post-widget-body{padding-left:80px}.widget_tag_cloud .widget-title-icon:before{content:"\f02c"}li.widget-post-list{padding:7px 0;position:relative}.latest-tweets-widget .widget-title-icon:before{content:"\e90f"}.social-icons-widget ul{margin:0 -3px}.social-icons-widget .social-icons-item{float:left;margin:3px;border-bottom:0;padding:0}.social-icons-widget .social-icons-item .social-link{width:40px;height:40px;line-height:40px;font-size:18px}@media (max-width:479px){.social-icons-widget .social-icons-item{float:none;display:inline-block}}.widget-posts-list-container{position:relative}@media (min-width:992px){.mega-menu .mega-menu-block{left:0;width:100%;padding:30px}.mega-menu .mega-menu-block a{width:auto}.main-menu .mega-cat-wrapper{overflow:hidden;height:auto;clear:both}.main-menu .mega-ajax-content{min-height:200px;position:relative}.main-menu .mega-recent-featured .mega-ajax-content{min-height:325px}.main-menu .mega-cat .mega-menu-content{clear:both}.main-menu .mega-cat .mega-menu-block{padding:0}.main-menu .mega-cat-content{padding:30px}.main-menu .horizontal-posts{width:100%}.main-menu .mega-recent-featured>.menu-sub-content{overflow:hidden}.main-menu .mega-recent-featured .mega-menu-content{float:right;position:relative;min-height:30px;width:100%}.main-menu .mega-recent-featured.menu-item-has-children .mega-menu-content{width:75%}.main-menu ul.mega-recent-featured-list{width:25%;padding-right:30px;float:left;position:relative;box-shadow:none}.main-menu .mega-recent-featured-list li{width:100%;z-index:2}.main-menu .mega-recent-featured-list a{display:block;padding:10px 0}.main-menu .mega-recent-featured-list:after{content:"";width:1500px;height:1500px;background:rgba(0,0,0,.03);position:absolute;z-index:1;right:0;top:-100px}}.breaking{float:left;width:100%;display:block!important}.breaking-title{padding:0 10px;display:block;float:left;color:#fff;font-size:12px;position:relative}.breaking-title span{position:relative;z-index:1}.breaking-title span.breaking-icon{display:none}@media (max-width:600px){.breaking-title span.breaking-icon{display:inline-block}.breaking-title .breaking-title-text{display:none}}.breaking-title:before{content:"";background:#f05555;width:100%;height:100%;position:absolute;left:0;top:0;z-index:0}.breaking-news{display:none}#mobile-container{display:none;padding:10px 30px 30px}#mobile-menu{margin-bottom:20px;position:relative;padding-top:15px}#mobile-social-icons{margin-bottom:15px}#mobile-social-icons ul{text-align:center;overflow:hidden}#mobile-social-icons ul .social-icons-item{float:none;display:inline-block}#mobile-social-icons .social-icons-item{margin:0}#mobile-social-icons .social-icons-item .social-link{background:0 0;border:none}#mobile-search .search-form{overflow:hidden;position:relative}#mobile-search .search-form:after{position:absolute;content:"\f002";font-family:'tiefonticon';top:4px;right:10px;line-height:30px;width:30px;font-size:16px;border-radius:50%;text-align:center;color:#fff}#mobile-search .search-field{background-color:rgba(0,0,0,.05);border-color:rgba(255,255,255,.1);color:#fff;width:100%;border-radius:50px;padding:7px 45px 7px 20px}#mobile-search .search-submit{background:0 0;font-size:0;width:35px;height:38px;position:absolute;top:0;right:5px;z-index:1}#mobile-search input::-webkit-input-placeholder{color:rgba(255,255,255,.6)}#mobile-search input::-moz-placeholder{color:rgba(255,255,255,.6)}#mobile-search input:-moz-placeholder{color:rgba(255,255,255,.6)}#mobile-search input:-ms-input-placeholder{color:rgba(255,255,255,.6)}#tie-wrapper:after{position:absolute;z-index:1000;top:-10%;left:-50%;width:0;height:0;background:rgba(0,0,0,.2);content:'';opacity:0}@media (max-width:991px){.side-aside.appear-from-left{left:0;-webkit-transform:translate(-100%,0);-ms-transform:translate(-100%,0);transform:translate(-100%,0)}.side-aside.is-fullwidth{width:100%}}.is-desktop .side-aside .has-custom-scroll{padding:50px 0 0}.side-aside:after{position:absolute;top:0;left:0;width:100%;height:100%;background:rgba(0,0,0,.2);content:'';opacity:1}.side-aside .container-wrapper{padding:30px!important;border-radius:0;border:0;background:0 0;box-shadow:none!important}a.remove{position:absolute;top:0;right:0;display:block;speak:never;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;width:20px;height:20px;display:block;line-height:20px;text-align:center;font-size:15px}a.remove:before{content:"\e117";font-family:'tiefonticon';color:#e74c3c}a.remove.big-btn{width:25px;height:25px;line-height:25px;font-size:22px}a.remove.light-btn:not(:hover):before{color:#fff}.side-aside a.remove{z-index:1;top:15px;left:50%;right:auto;-webkit-transform:translateX(-50%);-ms-transform:translateX(-50%);transform:translateX(-50%)}.side-aside a.remove:not(:hover):before{color:#111}.side-aside.dark-skin a.remove:not(:hover):before{color:#fff}.tie-popup a.remove{-webkit-transform:scale(.2);-ms-transform:scale(.2);transform:scale(.2);opacity:0;top:15px;right:15px;z-index:1}.theiaStickySidebar:after{content:"";display:table;clear:both}.side-aside,.has-custom-scroll{overflow-x:hidden;scrollbar-width:thin}.side-aside::-webkit-scrollbar,.has-custom-scroll::-webkit-scrollbar{width:5px}.side-aside::-webkit-scrollbar-track,.has-custom-scroll::-webkit-scrollbar-track{background:0 0}.side-aside::-webkit-scrollbar-thumb,.has-custom-scroll::-webkit-scrollbar-thumb{border-radius:20px;background:rgba(0,0,0,.2)}.dark-skin .has-custom-scroll::-webkit-scrollbar-thumb{background:#000}.tie-popup{position:fixed;z-index:99999;left:0;top:0;height:100%;width:100%;background-color:rgba(0,0,0,.5);display:none;-webkit-perspective:600px;perspective:600px}.tie-popup-container{position:relative;z-index:100;width:90%;max-width:420px;margin:10em auto 0;border-radius:2px;box-shadow:0 0 20px rgba(0,0,0,.2);will-change:transform,opacity;-webkit-transform:scale(.5);-ms-transform:scale(.5);transform:scale(.5);opacity:0}.tie-popup-container .login-submit{padding-top:15px;padding-bottom:15px}.tie-popup-container .container-wrapper{padding:60px;background-color:#fff!important;border-radius:5px}@media (max-width:479px){.tie-popup-container .container-wrapper{padding:30px}}#tie-popup-adblock .tie-popup-container{max-width:500px}#tie-popup-adblock .container-wrapper{background:#e74c3c!important;text-align:center;color:#fff}#tie-popup-adblock .container-wrapper .tie-btn-close:before{color:#fff}#tie-popup-adblock .tie-adblock-icon{font-size:120px;margin-bottom:10px}#tie-popup-adblock .adblock-message{margin-top:10px}.pop-up-live-search{will-change:transform,opacity;-webkit-transform:scale(.7);-ms-transform:scale(.7);transform:scale(.7);opacity:0}.tie-popup-search-wrap::-webkit-input-placeholder{color:#fff}.tie-popup-search-wrap::-moz-placeholder{color:#fff}.tie-popup-search-wrap:-moz-placeholder{color:#fff}.tie-popup-search-wrap:-ms-input-placeholder{color:#fff}.tie-popup-search-wrap form{position:relative;height:80px;margin-bottom:20px}.popup-search-wrap-inner{position:relative;padding:80px 15px 0;margin:0 auto;max-width:800px}input.tie-popup-search-input{width:100%;height:80px;line-height:80px;background:rgba(0,0,0,.7)!important;font-weight:500;font-size:22px;border:0;padding-right:80px;padding-left:30px;color:#fff;border-radius:5px}button.tie-popup-search-submit{font-size:28px;color:#666;position:absolute;right:5px;top:15px;background:0 0!important}#tie-popup-search-mobile .popup-search-wrap-inner{padding-top:50px}#tie-popup-search-mobile input.tie-popup-search-input{height:50px;line-height:1;padding-left:20px;padding-right:50px}#tie-popup-search-mobile button.tie-popup-search-submit{font-size:16px;top:9px;right:0}#autocomplete-suggestions{overflow:auto;padding:20px;color:#eee;position:absolute;display:none;width:370px;z-index:9999;margin-top:15px}.tie-icon-facebook:before{content:"\f09a"}.tie-icon-search:before{content:"\f002"}.tie-icon-author:before{content:"\f007"}.tie-icon-home:before{content:"\f015"}.tie-icon-bookmark:before{content:"\f02e"}.tie-icon-ban:before{content:"\f05e"}.tie-icon-random:before{content:"\f074"}.tie-icon-phone:before{content:"\f095"}.tie-icon-twitter:before{content:"\e90f"}.tie-icon-navicon:before{content:"\f0c9"}.tie-icon-pinterest:before{content:"\f0d2"}.tie-icon-envelope:before{content:"\f0e0"}.tie-icon-linkedin:before{content:"\f0e1"}.tie-icon-bolt:before{content:"\f0e7"}.tie-icon-youtube:before{content:"\f16a"}.tie-icon-instagram:before{content:"\f16d"}.tie-icon-tumblr:before{content:"\f173"}.tie-icon-vk:before{content:"\f189"}.tie-icon-reddit:before{content:"\f1a1"}.tie-icon-paper-plane:before{content:"\f1d8"}.tie-icon-whatsapp:before{content:"\f232"}.tie-icon-odnoklassniki:before{content:"\f263"}.tie-icon-get-pocket:before{content:"\f265"}.tie-icon-fire:before{content:"\e900"}.tie-icon-moon:before{content:"\f10d"}.fas,.far,.fab{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;display:inline-block;font-style:normal;font-variant:normal;text-rendering:auto;line-height:1}.fa-android:before{content:"\f17b"}.fa-battery-half:before{content:"\f242"}.fa-bus-alt:before{content:"\f55e"}.fa-chart-bar:before{content:"\f080"}.fa-coffee:before{content:"\f0f4"}.fa-globe-americas:before{content:"\f57d"}.fa-hamburger:before{content:"\f805"}.fa-hire-a-helper:before{content:"\f3b0"}.fa-home:before{content:"\f015"}.fa-house-user:before{content:"\f965"}.fa-money-check-alt:before{content:"\f53d"}.fa-weight-hanging:before{content:"\f5cd"}.fab{font-family:'Font Awesome 5 Brands';font-weight:400}.far{font-family:'Font Awesome 5 Free';font-weight:400}.fas{font-family:'Font Awesome 5 Free';font-weight:900}.post-content.container-wrapper{padding:0}.entry-header{font-size:45px;line-height:1.2}@media (max-width:767px){.entry-header{font-size:28px}}.entry-header .entry-title{margin-bottom:15px}@media (max-width:767px){.entry-header .entry-title{font-size:28px}}.entry-header .post-cat{margin-bottom:6px}.entry-header .post-meta{overflow:inherit;font-size:12px;margin-top:5px;margin-bottom:0;line-height:24px}.entry-header .post-meta .meta-item{margin-right:12px}.entry-header .post-meta,.entry-header .post-meta a:not(:hover){color:#333}.entry-header .post-meta .meta-author{margin:0}.entry-header .post-meta .meta-author a{font-weight:600}.entry-header .post-meta .author-meta+.date:before{content:"22";color:#ccc;margin:0 3px 0 5px;display:inline-block}.entry-header .post-meta .tie-alignright{display:inline}@media (max-width:767px){.entry-header .post-meta{margin-bottom:-8px}.entry-header .post-meta .tie-alignright{float:none}.entry-header .post-meta .meta-item,.entry-header .post-meta .tie-alignright .meta-item:last-child{margin-bottom:8px!important}.entry-header .post-meta>span,.entry-header .post-meta>div{float:initial!important}.entry-header .post-meta .meta-author a{font-weight:400}.entry-header .meta-author-avatar img{width:20px;height:20px}}.meta-author-avatar img{width:30px;height:30px;margin-right:3px;margin-top:-5px;vertical-align:middle;border-radius:50%}.post-layout-1 .entry-header-outer{padding:30px 30px 20px}@media (max-width:767px){.post-layout-1 .entry-header-outer{padding:20px}}.post-layout-1 .entry-header{padding:0;margin:0}.featured-area{position:relative;margin-bottom:30px;line-height:1}@media (max-width:767px){.featured-area{margin-bottom:20px}}.featured-area img{width:100%}.single-featured-image{position:relative;margin:0;line-height:0}.share-buttons{padding:18px 28px;line-height:0}@media (max-width:767px){.share-buttons{padding:15px}}@media (min-width:768px){.share-buttons-top{padding-bottom:0}}.entry-header-outer+.share-buttons-top{padding-top:0}.post-layout-1 .share-buttons-top{padding-bottom:18px}.share-buttons-mobile{position:fixed;bottom:0;z-index:999999;width:100%;background:0 0;border:0 none;padding:0}.share-buttons-mobile .share-links a{margin:0;border-radius:0;width:1%;display:table-cell;opacity:1!important}.share-buttons-mobile .share-links a .share-btn-icon{margin:0 auto;float:none}@media (min-width:768px){.share-buttons-mobile{display:none}}.mobile-share-buttons-spacer{height:40px}@media (min-width:768px){.mobile-share-buttons-spacer{display:none}}.share-links a{color:#fff}.share-links{overflow:hidden;position:relative}.share-links .share-btn-icon{font-size:15px}.share-links a{display:inline-block;margin:2px;height:40px;overflow:hidden;position:relative;border-radius:2px;width:40px}.share-links a,.share-links a:before{background-color:#444}.share-links a .share-btn-icon{width:40px;height:40px;float:left;display:block;text-align:center;line-height:40px}.share-links a.facebook-share-btn,.share-links a.facebook-share-btn:before{background:#4080ff}.share-links a.twitter-share-btn,.share-links a.twitter-share-btn:before{background:#000}.share-links a.linkedin-share-btn,.share-links a.linkedin-share-btn:before{background:#238cc8}.share-links a.pinterest-share-btn,.share-links a.pinterest-share-btn:before{background:#e13138}.share-links a.reddit-share-btn,.share-links a.reddit-share-btn:before{background:#ff4500}.share-links a.tumblr-share-btn,.share-links a.tumblr-share-btn:before{background:#35465c}.share-links a.vk-share-btn,.share-links a.vk-share-btn:before{background:#45668e}.share-links a.odnoklassniki-share-btn,.share-links a.odnoklassniki-share-btn:before{background:#ee8208}.share-links a.pocket-share-btn,.share-links a.pocket-share-btn:before{background:#ef4056}.share-links a.whatsapp-share-btn,.share-links a.whatsapp-share-btn:before{background:#43d854}.share-links a.telegram-share-btn,.share-links a.telegram-share-btn:before{background:#08c}.share-links a.viber-share-btn,.share-links a.viber-share-btn:before{background:#773ead}@media (min-width:768px){a.whatsapp-share-btn,a.telegram-share-btn,a.viber-share-btn{display:none!important}}#related-posts .related-item{position:relative;float:left;width:33.333%;padding:0 15px;margin-bottom:20px}@media (max-width:767px){#related-posts .related-item{padding:0 8px}}#related-posts .related-item .post-thumb{margin-bottom:10px}#related-posts .related-item .post-title{font-size:14px;line-height:19px}#related-posts .related-item .post-meta{margin:4px 0 0}.has-sidebar .site-content #related-posts .related-item:nth-child(3n+1){clear:both}@media (max-width:767px){#related-posts .related-item{width:50%!important;clear:none!important}}#related-posts.has-extra-post .related-item:last-child{clear:none!important;display:none}@media only screen and (min-width:320px) and (max-width:767px){#related-posts.has-extra-post .related-item:last-child{display:block}}#cancel-comment-reply-link{float:right;line-height:18px}#reading-position-indicator{display:block;height:5px;position:fixed;bottom:0;left:0;background:var(--brand-color);box-shadow:0 0 10px rgba(0,136,255,.7);width:0;z-index:9999;max-width:100%}#check-also-box{position:fixed;background-color:#fff;z-index:999;bottom:15px;right:-1px;-webkit-transform:translatex(100%);-ms-transform:translatex(100%);transform:translatex(100%);width:340px;padding:30px;border:1px solid rgba(0,0,0,.1);border-radius:2px;border-top-right-radius:0;border-bottom-right-radius:0}#check-also-box .has-first-big-post .post-widget-body{clear:both}#check-also-box .posts-list-big-first li{padding-bottom:0}#check-also-box .posts-list-big-first li .post-title{font-size:18px;line-height:1.3em}@media (max-width:991px){#check-also-box{display:none}}#post-extra-info{display:none}#main-nav .main-menu>ul>li>a{text-transform:uppercase}:root:root{--brand-color:#e67e22;--dark-brand-color:#b44c00;--bright-color:#fff;--base-color:#2c2f34}#reading-position-indicator{box-shadow:0 0 10px rgba(230,126,34,.7)}:root:root{--brand-color:#e67e22;--dark-brand-color:#b44c00;--bright-color:#fff;--base-color:#2c2f34}#reading-position-indicator{box-shadow:0 0 10px rgba(230,126,34,.7)}.tie-cat-58{background-color:#e67e22!important;color:#fff!important}.tie-cat-58:after{border-top-color:#e67e22!important}@media (max-width:991px){.side-aside.normal-side{background:#2f88d6;background:-webkit-linear-gradient(135deg,#5933a2,#2f88d6);background:-moz-linear-gradient(135deg,#5933a2,#2f88d6);background:-o-linear-gradient(135deg,#5933a2,#2f88d6);background:linear-gradient(135deg,#2f88d6,#5933a2)}}
Molnupiravir nedir? İlaç ne işe yarıyor? Fiyatı ne kadar? - HAKANSEYHAN
İngiltere’de yeni tip koronavirüs tedavisinde Merck firmasının ürettiği molnupiravir adlı ilacın kullanımına şartlı yetki verildi. İngiltere Merck’in Kovid-19 antiviral ilacını onaylayan ilk ülke oldu. Dün ek olarak Avrupa Birliği’nin (AB) ilaç düzenleyicisi Avrupa İlaç Ajansı (EMA) “molnupiravir” adlı ilacın yeni tip koronavirüs (Kovid-19) tedavisinde acil durumlarda kullanılmasını tavsiye ettiğini duyurdu. Peki, molnupiravir nedir, ne işe yarıyor? İlacın fiyatı ne kadar? İşte detaylar…
İLACA NE ZAMAN ULAŞILACAK? İngiliz yetkililer vatandaşların, Molnupiravir adlı ilaca ulusal bir çalışmayla kış aylarında erişebileceğini açıkladı. İngiltere Sıhhat Bakanı Sajid Javid de “Bugün ülkemiz için zamanı bigün, zira İngiltere şu anda dünyada Kovid-19 için evde alınabilecek bir antivirali onaylayan ilk ülke.” dedi. Javid, İngiltere Ulusal Sıhhat Servisine (NHS) atıfta bulunarak yapmış olduğu açıklamada, “Molnupiravir’i mümkün olan en kısa sürede ulusal emek harcama kanalıyla hastalara dağıtma planı belirlemek için NHS ile beraber çalışıyoruz.” ifadelerini kullandı.
Doktorlar, tedavinin aşıya iyi cevap vermeyen kişiler için bilhassa mühim olacağını belirtiyor.
KİMLER, NASIL KULLANACAK? Şartlı yetkiyle Kovid-19 testi pozitif çıkan ve risk grubundaki 18 yaş üstü yetişkinlerin kullanımı için lisans alan ilacın, hastalığı evde hafifçe yada orta şiddette geçiren kişiler tarafınca 5 gün süresince günde iki doz kullanılması gerekiyor.
Semptomları azaltan ve iyileşmeyi hızlandıran ilacın, hastanelerdeki olay yüklerini hafifletmesi ve zayıf sıhhat sistemlerine haiz daha yoksul ülkelerde salgını engellemeye destek olması planlanıyor.
ABD Besin ve İlaç Dairesi de kasım sonunda ilacın güvenliğini ve etkinliğini incelemek suretiyle bağımsız uzmanlardan oluşan bir kurul toplayacağını duyurmuştu.
MOLNUPİRAVİR NEDİR? Hap, İngiltere’de Covid teşhisi konulmuş kırılgan hastalara günde iki kez verilecek. Peki, molnupiravir nedir? BBC’nin haberine bakılırsa ABD merkezli ilaç şirketi MSD ve Ridgeback Bioterapötiks tarafınca üretilen Molnupiravir, Covid tedavisinde kullanılan ilk hususi oral antiviral ilaç. Hap, virüsün kendi kopyalarını oluşturmak için kullandığı bir enzimi hedef alarak genetik kodunu zedeliyor. Bunun virüsün çoğalmasını engelleyerek, vücuttaki virüs seviyelerini düşük tutacağı ve hastalığın sertliğini azaltacağı öngörülüyor.
MSD, tedavinin koronavirüsün yeni varyantlarına karşı gelecekte de eşit derecede etkili olmasını beklediklerini söylemiş oldu. MHRA, ilacın hafifçe ve orta derecede Covid’i olan ve aşırı kiloluluk, yaşlılık, diyabet yada kalp hastalığı benzer biçimde ciddi hastalıklara yakalanma riskleri olan kişilerde kullanılmasına izin verildiğini belirtti.
ABD İLACIN HER DOZU İÇİN 700 DOLAR ÖDEMİŞTİ İngiltere, yıl sonuna kadar 480 bin doz Molnupiravir ilacı siparişi verdi. ABD merkezli ilaç şirketi Pfizer tarafınca geliştirilen, benzer bir ilaçtan da 250 bin doz almayı planlıyor.
MHRA Başkanı June Raine, “Covid-19’a karşı cephaneliğimizde yeni bir tedavi” söylediği Molnupiravir’in damar yerine ağızdan alınan ilk Covid ilacı bulunduğunun altını çizdi. Raine, “Bu mühim. Bu sebeple ilaç, Covid-19 ağır bir aşamaya ulaşmadan önce, hastane ortamı haricinde alınabiliyor” dedi.
ABD, ilacın 1,7 milyon dozunu ortalama 1.2 milyar dolara almıştı. Doğrusu ilacın her dozu için ortalama 700 dolar ödemişti. Avustralya, Singapur ve Cenup Kore’de satın alma anlaşmaları yapmıştı. İngiltere’nin ilaç için ne kadar ödeme yapmış olduğu bilinmiyor.
AB’DEN ACİL DURUMLARDA KULLANIM ONAYI Avrupa Birliği’nin (AB) ilaç düzenleyicisi Avrupa İlaç Ajansı (EMA) da dün yapmış olduğu açıklamada “molnupiravir” adlı ilacın yeni tip koronavirüs (Kovid-19) tedavisinde acil durumlarda kullanılmasını tavsiye ettiğini duyurdu. Ajansın aşı stratejisinden görevli yetkilisi Marco Cavaleri, molnupiravirin virüsün vücutta yayılmasını azaltabileceği, hastaneye yatış ve ölüm oranlarında düşüş sağlayabileceği sonucuna varıldığını açıkladı.
Cavaleri, EMA’nın AB ülkelerine bu tedaviyi pazarlama iznini beklemeden, acil kullanımlar için hazırlamalarını tavsiye ettiğini duyurdu.
Başa dön tuşu